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      2. 蛋清源生物活性肽功能及其構效關系研究進展
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        國家自然科學基金項目(31801549)


        Biological functions and structre-activity relationships of bioactive peptides derived from egg white proteins:a review
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          摘要:

          禽蛋為人類提供了豐富的營養物質,如蛋白質、脂質和維生素等。蛋清蛋白不僅具有許多功能性質,通過酶法制備獲得的蛋清肽還具有豐富的生物活性。然而,通過水解得到的蛋清源生物活性肽往往具有多種生物活性,且產量較低、結構差異較大,難以獲得普適的活性-結構關系結論。本文以鴨蛋蛋清蛋白和雞蛋蛋清蛋白為對象,綜述了蛋清肽的主要生物學功能如降血壓、抗氧化、促進礦物質吸收、降血糖、調節腸道健康等,探討了其結構-活性關系,并對蛋清源生物活性肽的后續深入研究進行了展望,以期為蛋清蛋白的高值化利用提供參考。

          Abstract:

          Eggs provide various of nutrients for human beings,such as proteins,lipids,and vitamins. Besides of the processing properties from egg white,bioactive peptides obtained by the enzymatic hydrolysis method have diversiform biological functions. In this paper,biological functions such as antihypertension,anti-oxidation,prevention of cardiovascular diseases,promoting mineral absorption,anti-diabetes,and regulating intestinal health were summarized,and the structure-activity relationships of egg white peptides from duck egg and chicken egg were also reviewed. It was found that egg white-derived angiotensin-converting enzyme (ACE) inhibitory peptides could affect their ACE inhibitory activity when the C-terminal was proline,leucine,and the N-terminal was aromatic or alkaline amino acid. Hydrophobic amino acids in N-terminal,and aromatic amino acids in the primary structure of antioxidant peptides from egg white can greatly improve the antioxidant capacity of the peptides. Glutamic acid in the first C-terminal,and phosphorylation of serine in the sequence of egg white-derived calcium absorption peptides play an important in the calcium absorption. However,bioactive peptides obtained by hydrolysis were confirmed to have different bioactivities,low yield and significantly different structures,making it difficult to obtain universal structure-activity relationship conclusions. Thus,the purpose of this paper is to provide a basis for the high-valued utilization of egg white,and a certain application for the production of egg white bioactive peptides as nutritional supplements,functional nutritional health products and therapeutic drugs,as well as to put forward a new prospect for the research of bioactive peptides.

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        趙夢鴿,何慧,馬愛民,侯燾.蛋清源生物活性肽功能及其構效關系研究進展[J].華中農業大學學報,2020,39(5):167-175

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        • 收稿日期:2020-05-22
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        • 在線發布日期: 2020-10-05
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