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      2. 不同營養類型植物病原真菌次生代謝產物合成基因簇的差異性研究
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        國家自然科學基金項目(31960314);云南省應用基礎研究計劃項目(2018FG001-028);云南省研發經費投入補助項目(2016YB462&2017YB236)


        Differences in gene clusters of synthesizing secondary metabolites of plant pathogenic fungi with different nutritional types
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          摘要:

          選擇全基因組序列已經公布的22種真菌為研究對象,利用antiSMASH數據庫對不同營養類型真菌的次生代謝產物合成基因簇進行注釋,以期發現不同營養類型植物病原真菌在侵染植物過程中次生代謝產物所發揮的作用及合成基因簇的差異性。結果表明:半活體營養型真菌和死體營養型真菌中次生代謝產物合成基因簇的種類和數量都高于活體營養型真菌;進一步對非核糖體肽合成酶(NRPS)、聚酮合酶(PKS)、萜烯(terpene)三大類次生代謝產物合成基因簇進行分析,發現半活體營養型和死體營養型病原菌中NRPS基因簇、PKS基因簇和萜烯基因簇的數量也都高于活體營養型病原菌。

          Abstract:

          Twenty-two fungi with whole genome sequence published and the antiSMASH database were used to classify and annotate the gene clusters of synthesizing secondary metabolites of plant pathogenic fungi with different nutritional types in order to clarify the role of secondary metabolites of plant pathogenic fungi with different nutritional types in infecting plants and the differences in gene clusters. The results showed that the type and number of gene clusters of synthesizing secondary metabolites of hemi-biotrophs and necrotrophs fungi were higher than that of biotrophs fungi. The results of further analyzing the gene clusters of synthesizing secondary metabolites of non-ribosomal peptide synthetase,polyketide synthase and terpene showed that the number of NRPS gene clusters,PKS gene clusters and terpene gene clusters in hemi-biotrophs and necrotrophs pathogenic fungi were higher than that in biotrophs pathogenic fungi as well. It will provide an important theoretical basis for further analyzing the function of the gene cluster of synthesizing secondary metabolites of different trophic types of fungi and identifying new drug targets. Analyzing the gene clusters of synthesizing secondary metabolites in fungi and clarifying the differences in gene clusters of synthesizing secondary metabolites of different nutrition types of fungi is conducive to the better development of medicaments for preventing and controlling novel action targets of plant diseases.

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        祝友朋,韓長志.不同營養類型植物病原真菌次生代謝產物合成基因簇的差異性研究[J].華中農業大學學報,2020,39(6):37-43

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        • 收稿日期:2020-06-23
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        • 在線發布日期: 2020-12-01
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